Who are "all who are in Asia" of whom Paul speaks in 2 Timothy 1:15? Today, Asia is an entire continent. Were those in Paul's day even aware of continents? Often, bible maps show "Asia" as what we know to be modern day Turkey. Paul, born in Tarsus on the southern coast of the Roman province of Cilicia, would be Turkish if he were from our world.
Paul traveled extensively in "Asia". If we apply our current knowledge of Asia to Paul's travels then he traveled very far indeed! So, this might seem trivial, what exactly was "Asia"? As we read read through the bible we often apply our current social and cultural thoughts into what we read; this also can happen geographically. When you read "all those in Asia" does it not sound as though everyone has turned from Paul? At least everyone but those in Rome and Greece? I used to read this passage like that, hopelessness. But, if we due our due diligence, we will find that Paul did not see all as turning away, but only one Roman province. Asia was a Roman province which included Ephesus, Colossae, Laodicia, Troa, and Hierolpolis.